Two Modes of Tumor Kill

Concentrated, sustained targeted delivery of our submicron particles results in persistent direct tumor kill causing a pronounced local immune response with preliminary signs of secondary immune-mediated tumor kill.

NANO_IMMUNEPG BALLS_Fin
NanOlogy is Evaluating Two Modes of Tumor Kill Through Disruption of the Tumor Microenvironment via Local, Sustained Delivery
Preclinical Examples of Increased Immune Response

Bladder Cancer (UMUC-3/Mice) Treated with
Intratumoral NanoDoce

F4-80 brown stain shows macrophages in and around dead and dying tumor.  Negative control shows viable tumor cells.
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Bladder Cancer (UMUC-3/Mice) Treated with Intratumoral NanoDoce F4-80 brown stain shows macrophages in and around dead and dying tumor. Negative control shows viable tumor cells.

Negative Control

Bladder Cancer (UMUC-3/Mice) Treated with
Intratumoral NanoDoce

CD16 brown stain shows admixture of natural killers, macrophages, monocytes around in and around dead and dying tumor. Negative control shows viable tumor cells.

Bladder Cancer (UMUC-3/Mice) Treated with Intratumoral NanoDoce CD16 brown stain shows admixture of natural killers, macrophages, monocytes around in and around dead and dying tumor. Negative control shows viable tumor cells.

Negative Control

Non-Small Cell Lung Cancer (Calu-3/Rat) Treated with Inhaled NanoPac
CD11b brown stain shows admixture of natural killers, macrophages, dendritic cells in and around dead and dying tumor.  Negative control shows viable tumor cells.

Non-Small Cell Lung Cancer (Calu-3/Rat) Treated with Inhaled NanoPac CD11b brown stain shows admixture of natural killers, macrophages, dendritic cells in and around dead and dying tumor. Negative control shows viable tumor cells.

Negative Control


References:  Maulhardt et al, Cancers, 2019.  Verco et al, JAMPDD, 2019. NanOlogy internal data, 2015-2019.