Soria

DFB Soria LLC is an affiliate of NanOlogy and is owned and operated by DFB Pharmaceuticals.  Soria entered into an exclusive worldwide license with CritiTech for use of its submicron particle production technology in certain fields outside of oncology including dermatology.
Technology
The key scientific advance in our submicron particle production technology is the patented use of sonic energy and super critical fluid carbon dioxide to reduce unprocessed paclitaxel API crystals by up to 400 times into patented, stable, uncoated particles of paclitaxel with exponentially increased surface area and unique geometry. The paclitaxel particles are suspended in a patent-pending preservative-free anhydrous base that was designed to optimize epithelial and dermal penetration. Learn more about the Technology.
Products
Our topical submicron particle paclitaxel has demonstrated dermal penetration in vitro, completed an in vivo dermal toxicity study, and shown negligible systemic absorption along with no adverse systemic effects in a phase 1 clinical trial. The product is under clinical investigation for cutaneous metastases (via license to NanOlogy) and has completed a phase 2 trial in actinic keratosis. It is also under preclinical evaluation for cervical intraepithelial neoplasia.
Clinical Programs

Clinical Trials of our Submicron Particle Paclitaxel in an Anhydrous Base

Phase 2 Clinical Trial:  Open-label, dose-rising trial under evaluation for the treatment of cutaneous metastases from non-melanoma cancers (via license to NanOlogy).
Phase 2 Clinical Trial Completed in July 2018:  Randomized, double-blind, dose rising study to determine the safety, tolerability, and preliminary efficacy of four concentrations of the product compared to placebo for actinic keratosis (AK) lesions.
Pipeline
See the complete NanOlogy & Soria Pipeline.