Enabled by a proprietary particle engineering technology, LSAMs of pure drug are suspended at time of use and delivered directly to the disease site where the particles are retained as a depot continuously releasing drug molecules as the particles dissolve.

Large Surface Area Microparticles (LSAMs)
  • Intratumoral
  • Peritumoral
  • Intraperitoneal
  • Resection bed
  • Intravesicular
  • Instillation
  • Inhalation
  • Intracystic
  • Topical


High sustained local concentration

Continuous tumor kill

Immunogenic effect

Gradual subtoxic clearance

Composition of matter patent on LSAMs protects particle regulatory specifications:


Surface Area



LSAMs are Superior to IV Drugs for IT Delivery

Taxane Solution for Injection

Tumor Site

Paclitaxel or docetaxel injection are designed for IV administration and quickly diffuse out of the tumor if injected intratumorally.
NanoPac or NanoDoce Suspension
NanoPac or NanoDoce microparticles are designed for local administration and become entrapped in the tumor allowing for sustained therapeutic drug release

Tumor tissue concentration of NanoPac® and NanoDoce® versus comparators all given intratumorally in a mouse model

Adapted from Verco, S., Maulhardt, H., Baltezor, M. et al. Drug Deliv. and Transl. Res. (2020). ABRAXANE® is a registered trademark of Abraxis Bioscience LLC, a Bristol-Myers Squibb company.
Proprietary SCP Technology Platform
Large Surface Area Microparticle (LSAM) Production
API Crystals
  • Large and bulky crystals
  • Large distribution around particle size mean with large clumps
  • Poor uniformity of suspensions
  • Poor drug release due to small surface area
  • Limited to dissolution in solvent as a solution for IV delivery
  • API crystals dissolved in organic solvent and injected into precipitation chamber
  • Sonicated into small uniform droplets via sonic probe
  • Solvent stripped away from droplets via supercritical fluid carbon dioxide
  • Stable microparticles of pure drug precipitated and collected on harvesting filters
  • Platform for multiple drug classes
  • Narrow particle size distribution around mean
  • Microparticles suspended in saline-based fluid for local delivery
  • Excellent suspension uniformity
  • Disproportionately large surface area to particle size ratio allows for:
    • Particle entrapment
    • Therapeutic drug release
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References:  NanOlogy internal data, 2015-2022.